Linked Life Data

19481029

Source:http://linkedlifedata.com/resource/pubmed/id/19481029

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pubmed-article:19481029pubmed:abstractTextPulmonary arterial hypertension (PAH) is a life-threatening disease of the pulmonary arterioles, which, in the absence of effective therapy, progresses rapidly to right heart failure and death. Opening of a patent foramen ovale (PFO) is common in patients with severe pulmonary hypertension (PH), resulting in resistive hypoxemia. We report the case of a 40-year-old woman with idiopathic pulmonary hypertension (iPAH) in New York Heart Association (NYHA) class III to IV, who was admitted in the intensive care unit with hemodynamic compromise and severe hypoxemia due to right-to-left shunt throughout a PFO. Combination therapy initially with inhaled iloprost and sildenafil, and then addition of an endothelin A receptor-selective antagonist (sitaxsentan), resulted in impressive improvement in oxygenation with reversal of the right-to-left shunt and marked improvement in functional class of the patient.lld:pubmed
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pubmed-article:19481029pubmed:year2009lld:pubmed
pubmed-article:19481029pubmed:articleTitleSuccessful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy?lld:pubmed
pubmed-article:19481029pubmed:affiliationRespiratory Failure Unit, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.lld:pubmed
pubmed-article:19481029pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19481029pubmed:publicationTypeCase Reportslld:pubmed