Linked Life Data

19420516

Source:http://linkedlifedata.com/resource/pubmed/id/19420516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2009-5-7
pubmed:abstractText
We report molecular-dynamics simulation of carbon-nanotube-based drug delivery and release systems. We show that a peptide encapsulated inside or attached to the outer surface of a carbon nanotube can be released by another nanotube through a competitive replacement process. Energy analysis reveals that the van der Waals interaction plays the key role in this process, and the potential well between two nanotubes drives the competitive replacement. We further show that competitive replacement is a basic principle which may be generally explored for drug release. For example, one type of peptide can be used to replace/release another type of peptide, depending on the difference in their affinity for the nanotube. The effects of the peptide sequence and the nanotube size on the drug release process are also studied in this paper.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1361-6528
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145101
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Molecular-dynamics studies of competitive replacement in peptide-nanotube assembly for control of drug release.
pubmed:affiliation
Institute of High Performance Computing, Singapore 138632, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't