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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-5-18
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pubmed:abstractText |
Solid tumors often develop an acidic environment due to the Warburg effect. The effectiveness of diagnosis and therapy may therefore be enhanced by the design and use of pH-sensitive agents that target acidic tumors. Recently, a novel technology was introduced to target acidic tumors using pH low insertion peptide (pHLIP), a peptide that inserts across cell membranes as an alpha-helix when the extracellular pH (pH(e)) is acidic. In this study, we expanded the application of the pHLIP technology to include positron emission tomography imaging of the acidic environment in prostate tumors using (64)Cu conjugated to the pHLIP ((64)Cu-DOTA-pHLIP). Studies showed that this construct avidly accumulated in LNCaP and PC-3 tumors, with higher uptake and retention in the LNCaP tumors. Uptake correlated with differences in the bulk pH(e) of PC-3 and LNCaP tumors measured in magnetic resonance spectroscopy experiments by the (31)P chemical shift of the pH(e) marker 3-aminopropylphosphonate. This article introduces a novel class of noninvasive pH-selective positron emission tomography imaging agents and opens new research directions in the diagnosis of acidic solid tumors.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/F32 CA110422-03,
http://linkedlifedata.com/resource/pubmed/grant/P30 CA091842-080008,
http://linkedlifedata.com/resource/pubmed/grant/P30 CA91842,
http://linkedlifedata.com/resource/pubmed/grant/R01 133890,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA133890-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM073857,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM073857-03,
http://linkedlifedata.com/resource/pubmed/grant/R21 CA125280,
http://linkedlifedata.com/resource/pubmed/grant/R21 CA125280-02,
http://linkedlifedata.com/resource/pubmed/grant/R24 CA083060-08,
http://linkedlifedata.com/resource/pubmed/grant/R24 CA83060
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-10362108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-10470364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-10933074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-11216519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-11330256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-11522650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-11870907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-12353258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-14998334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-15623652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-15693655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-15750159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16402385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16513837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16608910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16818644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16868303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-16915294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-17020978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-17204700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-17483464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-17557792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-17992274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-18829441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-8048479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-8916017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-9004284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-9080473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19417132-9744499
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1538-7445
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4510-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19417132-Amino Acid Sequence,
pubmed-meshheading:19417132-Animals,
pubmed-meshheading:19417132-Chromatography, High Pressure Liquid,
pubmed-meshheading:19417132-Copper Radioisotopes,
pubmed-meshheading:19417132-Humans,
pubmed-meshheading:19417132-Hydrogen-Ion Concentration,
pubmed-meshheading:19417132-Male,
pubmed-meshheading:19417132-Maleimides,
pubmed-meshheading:19417132-Membrane Proteins,
pubmed-meshheading:19417132-Mice,
pubmed-meshheading:19417132-Mice, Nude,
pubmed-meshheading:19417132-Models, Animal,
pubmed-meshheading:19417132-Molecular Sequence Data,
pubmed-meshheading:19417132-Positron-Emission Tomography,
pubmed-meshheading:19417132-Prostatic Neoplasms
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pubmed:year |
2009
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pubmed:articleTitle |
A novel technology for the imaging of acidic prostate tumors by positron emission tomography.
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pubmed:affiliation |
Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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