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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-7-17
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pubmed:abstractText |
Embelin has been reported to exhibit therapeutic activity in cancer. In this study glioblastoma cells and human astrocytes were treated with Embelin, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or the combination of both. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively. Furthermore, Embelin down-regulated the expression of the long- and short-isoform of c-FLIP. In addition, forced expression of the short isoform of c-FLIP (S) attenuated apoptosis induced by the combination of Embelin and TRAIL. Embelin did not modulate the mRNA levels of c-FLIP (S), suggesting that Embelin modulates the expression of c-FLIP in a posttranscriptional manner. In summary, the short isoform of c-FLIP is a key regulator in TRAIL-Embelin-mediated apoptosis in malignant glioma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/X-Linked Inhibitor of Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/XIAP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/embelin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1872-9754
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-30
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pubmed:meshHeading |
pubmed-meshheading:19409438-Antineoplastic Agents,
pubmed-meshheading:19409438-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19409438-Apoptosis,
pubmed-meshheading:19409438-Apoptosis Regulatory Proteins,
pubmed-meshheading:19409438-Benzoquinones,
pubmed-meshheading:19409438-Brain Neoplasms,
pubmed-meshheading:19409438-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:19409438-Cell Line,
pubmed-meshheading:19409438-Cell Line, Tumor,
pubmed-meshheading:19409438-Down-Regulation,
pubmed-meshheading:19409438-Drug Synergism,
pubmed-meshheading:19409438-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19409438-Glioma,
pubmed-meshheading:19409438-Humans,
pubmed-meshheading:19409438-Protein Isoforms,
pubmed-meshheading:19409438-RNA, Messenger,
pubmed-meshheading:19409438-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:19409438-X-Linked Inhibitor of Apoptosis Protein
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pubmed:year |
2009
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pubmed:articleTitle |
The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.
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pubmed:affiliation |
Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany. msiegelin@t-online.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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