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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-7-18
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pubmed:abstractText |
Synchronized murine 3T3 cells have been used to investigate the possible dependency of murine cytomegalovirus replication upon the cell cycle. The normal latent period of 12 h characteristic of asynchronous 3T3 cells was protracted to more than 24 h after an early G1 infection in synchronous cells. In this case viral progeny were not detected until after the initiation of the host S-phase. Cells maintained in the G1 phase did not replicate virus. This failure could not be explained by a decrease in virus penetration but was apparently due to a requirement for an event associated with the host S-phase. Thymidine-induced inhibition of cell cycle traverse also blocked virus replication. Viral DNA synthesis did not initiate until after the initiation of host DNA. In contrast, herpes simplex virus type 1 replicated in 3T3 cells independently of the cell cycle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-14008663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-14109144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-171846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-176471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-176789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-178912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-180668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-180669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4123459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4254680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4296905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4302185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4348850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4365718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4370817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4555254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-4571496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-5102151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194054-5241531
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:194054-Animals,
pubmed-meshheading:194054-Cell Division,
pubmed-meshheading:194054-Cells, Cultured,
pubmed-meshheading:194054-Cytological Techniques,
pubmed-meshheading:194054-Cytomegalovirus,
pubmed-meshheading:194054-DNA,
pubmed-meshheading:194054-DNA, Viral,
pubmed-meshheading:194054-Mice,
pubmed-meshheading:194054-Thymidine,
pubmed-meshheading:194054-Virus Replication
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pubmed:year |
1977
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pubmed:articleTitle |
Cell cycle dependency of murine cytomegalovirus replication in synchronized 3T3 cells.
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pubmed:publicationType |
Journal Article
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