| pubmed-article:19401563 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0081620 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C2698420 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C1366480 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C1417834 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0017033 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19401563 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:19401563 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19401563 | pubmed:dateCreated | 2009-7-3 | lld:pubmed |
| pubmed-article:19401563 | pubmed:abstractText | Increased fetal hemoglobin expression in adulthood is associated with acute stress erythropoiesis. However, the mechanisms underlying gamma-globin induction during the rapid expansion of adult erythroid progenitor cells have not been fully elucidated. Here, we examined COUP-TFII as a potential repressor of gamma-globin gene after stem cell factor (SCF) stimulation in cultured human adult erythroid progenitor cells. We found that COUP-TFII expression is suppressed by SCF through phosphorylation of serine/threonine phosphatase (PP2A) and correlated well with fetal hemoglobin induction. Furthermore, down-regulation of COUP-TFII expression with small interfering RNA (siRNA) significantly increases the gamma-globin expression during the erythroid maturation. Moreover, SCF-increased expression of NF-YA associated with redox regulator Ref-1 and cellular reducing condition enhances the effect of SCF on gamma-globin expression. Activation of Erk1/2 plays a critical role in SCF modulation of downstream transcriptional factor COUP-TFII, which is involved in the regulation of gamma-globin gene induction. Our data show that SCF stimulates Erk1/2 MAPK signaling pathway, which regulates the downstream repressor COUP-TFII by inhibiting serine/threonine phosphatase 2A activity, and that decreased COUP-TFII expression resulted in gamma-globin reactivation in adult erythropoiesis. These observations provide insight into the molecular pathways that regulate gamma-globin augmentation during stress erythropoiesis. | lld:pubmed |
| pubmed-article:19401563 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19401563 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19401563 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19401563 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19401563 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19401563 | pubmed:author | pubmed-author:RodgersGriffi... | lld:pubmed |
| pubmed-article:19401563 | pubmed:author | pubmed-author:AerbajinaiWul... | lld:pubmed |
| pubmed-article:19401563 | pubmed:author | pubmed-author:ChinKyungK | lld:pubmed |
| pubmed-article:19401563 | pubmed:author | pubmed-author:ZhuJianqiongJ | lld:pubmed |
| pubmed-article:19401563 | pubmed:author | pubmed-author:KumkhaekChuti... | lld:pubmed |
| pubmed-article:19401563 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19401563 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:19401563 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19401563 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19401563 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19401563 | pubmed:pagination | 187-94 | lld:pubmed |
| pubmed-article:19401563 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
| pubmed-article:19401563 | pubmed:meshHeading | pubmed-meshheading:19401563... | lld:pubmed |
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| pubmed-article:19401563 | pubmed:meshHeading | pubmed-meshheading:19401563... | lld:pubmed |
| pubmed-article:19401563 | pubmed:meshHeading | pubmed-meshheading:19401563... | lld:pubmed |
| pubmed-article:19401563 | pubmed:meshHeading | pubmed-meshheading:19401563... | lld:pubmed |
| pubmed-article:19401563 | pubmed:meshHeading | pubmed-meshheading:19401563... | lld:pubmed |
| pubmed-article:19401563 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19401563 | pubmed:articleTitle | SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII. | lld:pubmed |
| pubmed-article:19401563 | pubmed:affiliation | Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-2560, USA. | lld:pubmed |
| pubmed-article:19401563 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19401563 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19401563 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19401563 | lld:pubmed |
