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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0036341,
umls-concept:C0073393,
umls-concept:C0439849,
umls-concept:C0683150,
umls-concept:C0871261,
umls-concept:C1176140,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2010-6-17
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pubmed:abstractText |
In this study, we examined the relationships between plasma concentrations of risperidone and 9-hydroxyrisperidone and polymorphisms of CYP3A4. All 130 schizophrenia patients (45 men, 85 women, age 15-60 years) who met DSM-IV criteria were given risperidone for 8 weeks. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS). CYP3A4*1G was found to be associated with the change in total PANSS scores (Kruskal-Wallis test, P = 0.021), which was not significant on adjusting for multiple testing. Our study has, for the first time, conducted a genetic association study of the CYP3A4 gene with risperidone response. Further studies on larger groups and on the effects of the longer term risperidone treatment are needed to confirm these results.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1461-7285
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pubmed:author |
pubmed-author:CidLL,
pubmed-author:EMSS,
pubmed-author:FOXJ EJE,
pubmed-author:FOXJ TJT,
pubmed-author:FendJJ,
pubmed-author:LULL,
pubmed-author:LiuSS,
pubmed-author:WangLL,
pubmed-author:XingQQ,
pubmed-author:XuanJJ,
pubmed-author:YuLL,
pubmed-author:ZhangAA
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1115-20
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pubmed:meshHeading |
pubmed-meshheading:19395426-Adolescent,
pubmed-meshheading:19395426-Adult,
pubmed-meshheading:19395426-Antipsychotic Agents,
pubmed-meshheading:19395426-Cytochrome P-450 CYP2D6,
pubmed-meshheading:19395426-Cytochrome P-450 CYP3A,
pubmed-meshheading:19395426-DNA,
pubmed-meshheading:19395426-Dose-Response Relationship, Drug,
pubmed-meshheading:19395426-Female,
pubmed-meshheading:19395426-Genotype,
pubmed-meshheading:19395426-Humans,
pubmed-meshheading:19395426-Isoxazoles,
pubmed-meshheading:19395426-Male,
pubmed-meshheading:19395426-Middle Aged,
pubmed-meshheading:19395426-Polymorphism, Genetic,
pubmed-meshheading:19395426-Psychiatric Status Rating Scales,
pubmed-meshheading:19395426-Pyrimidines,
pubmed-meshheading:19395426-Risperidone,
pubmed-meshheading:19395426-Schizophrenia,
pubmed-meshheading:19395426-Schizophrenic Psychology,
pubmed-meshheading:19395426-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Relationship between response to risperidone, plasma concentrations of risperidone and CYP3A4 polymorphisms in schizophrenia patients.
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pubmed:affiliation |
Bio-X Center, Shanghai JiaoTong University, Shanghai, China, Shanghai Institute of Planned Parenthood Research, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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