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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-6-3
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pubmed:abstractText |
Chronic hepatitis C virus (HCV) infection affects nearly 170 million individuals worldwide. Treatment of HCV with pegylated interferon-alpha-2a is successful in eradicating virus from only 30 to 80% of those treated. Interleukin-6 (IL-6) is an important cytokine involved in the immune response to infectious agents and in vitro studies suggest that host genetic variation, particularly haplotypes, may affect IL-6 expression. We examined the contribution of haplotypes in the IL-6 gene on sustained viral response (SVR) to the therapy for chronic HCV infection. We observed the IL-6 T-T-G-G-G-G-C-A-G-A haplotype to be associated with a lower risk of achieving SVR among Caucasian Americans (CAs) ((relative risk) RR=0.80; 95% CI: 0.66-0.98; P=0.0261). Using a sliding window approach, the rs1800797-(G)-rs1800796-(G)-rs1800795-(G) haplotype was associated with a reduced chance of SVR (RR=0.79; 95% CI: 0.66-0.94; P=0.0081), as was the rs1800796-(G)-rs1800795-(G)-rs2069830-(C) haplotype (RR=0.78; 95% CI: 0.66-0.94; P=0.0065) among CAs. Overall, the rs1800797-(G)-rs1800796-(G)-rs1800795-(G) haplotype was independently associated with a reduced chance of SVR (RR=0.78; 95% CI: 0.62-1.0; P=0.0489) after adjustment for potential confounding factors. Our findings further illustrate the complexity of IL-6 genetic regulation and the potential importance of haplotypes on IL-6 expression. Our findings provide additional support for the potential importance of genetic variation in the IL-6 gene and the response to HCV therapy.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/1KL2 RR024154-02,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000042,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR00046,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR00645,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR16500,
http://linkedlifedata.com/resource/pubmed/grant/M02 RR000079,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK060341-05,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60309,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60324,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60327,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60329,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60335,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60340,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60341,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60342,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60344,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60345,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60346,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60349,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK60352,
http://linkedlifedata.com/resource/pubmed/grant/Z01 DK054511-02,
http://linkedlifedata.com/resource/pubmed/grant/Z99 DK999999,
http://linkedlifedata.com/resource/pubmed/grant/ZIA DK054511-03
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-10422197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-10747905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-10827107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-10835412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-11583749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-12407599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-15033648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-15163776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-15185312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-16107838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-16702586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-16774684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-16890601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-17258724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-17526009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-17668881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-7560864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19387461-9769329
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1476-5470
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19387461-Adult,
pubmed-meshheading:19387461-Alleles,
pubmed-meshheading:19387461-Cohort Studies,
pubmed-meshheading:19387461-Female,
pubmed-meshheading:19387461-Gene Expression Regulation,
pubmed-meshheading:19387461-Gene Frequency,
pubmed-meshheading:19387461-Genotype,
pubmed-meshheading:19387461-Haplotypes,
pubmed-meshheading:19387461-Hepacivirus,
pubmed-meshheading:19387461-Hepatitis C, Chronic,
pubmed-meshheading:19387461-Humans,
pubmed-meshheading:19387461-Interferon-alpha,
pubmed-meshheading:19387461-Interleukin-6,
pubmed-meshheading:19387461-Male,
pubmed-meshheading:19387461-Middle Aged,
pubmed-meshheading:19387461-Multivariate Analysis,
pubmed-meshheading:19387461-Polyethylene Glycols,
pubmed-meshheading:19387461-Polymorphism, Single Nucleotide,
pubmed-meshheading:19387461-Recombinant Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.
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