rdf:type |
|
lifeskim:mentions |
umls-concept:C0003242,
umls-concept:C0021013,
umls-concept:C0162801,
umls-concept:C0205147,
umls-concept:C0439828,
umls-concept:C0443288,
umls-concept:C0679058,
umls-concept:C1414406,
umls-concept:C1417166,
umls-concept:C1522424,
umls-concept:C1547699,
umls-concept:C2700640
|
pubmed:issue |
2
|
pubmed:dateCreated |
1991-12-13
|
pubmed:databankReference |
|
pubmed:abstractText |
We have sequenced the cDNAs encoding the variable (V) regions from the light and heavy chains of a monoclonal anti-idiotypic antibody (Ab), designated MC1, that, when used as an immunogen, activates regulatory idiotypes associated with anti-HIV-1 gp 160 responses. This anti-Id represents a non-antigen-mimicking subclass of Ab-2 referred to as non-internal image. The gene family selections and sequence homologies are presented.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp160,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Variable Region,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0378-1119
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
105
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
283-4
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1937027-Amino Acid Sequence,
pubmed-meshheading:1937027-Animals,
pubmed-meshheading:1937027-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1937027-Antibodies, Monoclonal,
pubmed-meshheading:1937027-Base Sequence,
pubmed-meshheading:1937027-DNA,
pubmed-meshheading:1937027-Gene Products, env,
pubmed-meshheading:1937027-HIV,
pubmed-meshheading:1937027-HIV Antibodies,
pubmed-meshheading:1937027-HIV Envelope Protein gp160,
pubmed-meshheading:1937027-Immunoglobulin Variable Region,
pubmed-meshheading:1937027-Mice,
pubmed-meshheading:1937027-Molecular Sequence Data,
pubmed-meshheading:1937027-Protein Precursors
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pubmed:year |
1991
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pubmed:articleTitle |
Sequence analysis of the variable region of a mouse gene encoding a monoclonal anti-idiotypic antibody that detects a restricted idiotype on anti-HIV-1 gp160.
|
pubmed:affiliation |
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|