Linked Life Data

19319911

Source:http://linkedlifedata.com/resource/pubmed/id/19319911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-14
pubmed:abstractText
The stunning possibility of "reprogramming" differentiated somatic cells to express a pluripotent stem cell phenotype (iPS, induced pluripotent stem cell) and the "ground state" character of pluripotency reveal fundamental features of cell fate regulation that lie beyond existing paradigms. The rarity of reprogramming events appears to contradict the robustness with which the unfathomably complex phenotype of stem cells can reliably be generated. This apparent paradox, however, is naturally explained by the rugged "epigenetic landscape" with valleys representing "preprogrammed" attractor states that emerge from the dynamical constraints of the gene regulatory network. This article provides a pedagogical primer to the fundamental principles of gene regulatory networks as integrated dynamic systems and reviews recent insights in gene expression noise and fate determination, thereby offering a formal framework that may help us to understand why cell fate reprogramming events are inherently rare and yet so robust.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1521-1878
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546-60
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Reprogramming cell fates: reconciling rarity with robustness.
pubmed:affiliation
Institute for Biocomplexity and Informatics, University of Calgary, Calgary, AB, Canada. Sui.huang@ucalgary.ca
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural