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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-12-26
|
| pubmed:abstractText |
A growing body of evidence from clinical phenomenology, including associated disorders, brain imaging, and neuropharmacologic studies, links the classic psychiatric syndrome of obsessive-compulsive disorder (OCD) to basal ganglia dysfunction and to the serotonin system. At present, OCD is the psychiatric syndrome for which a specific neurologic dysfunction is most strongly suggested, and for which a particularly compelling animal model has been found. It is proposed that dysfunction of basal ganglia-thalamic frontal cortical loops produce "positive" symptoms of excessive grooming, checking, and doubt most common in OCD. Perhaps most intriguing are preliminary data from clinical trials that a spectrum of other abnormal behaviors resembling excessive grooming in both animals and humans may be related to OCD. An ethologic perspective is suggested.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0893-133X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-10
|
| pubmed:dateRevised |
2011-5-18
|
| pubmed:meshHeading | |
| pubmed:year |
1991
|
| pubmed:articleTitle |
Recent advances in obsessive-compulsive disorder.
|
| pubmed:affiliation |
National Institute of Mental Health, Child Psychiatry Branch, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article,
Review
|