| pubmed-article:19251052 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19251052 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:19251052 | lifeskim:mentions | umls-concept:C0021655 | lld:lifeskim |
| pubmed-article:19251052 | pubmed:dateCreated | 2009-3-2 | lld:pubmed |
| pubmed-article:19251052 | pubmed:abstractText | Chronic low-grade inflammation has been well recognized as a key feature of obesity that is correlated with insulin resistance and type 2 diabetes. Among the adipose-secreted factors (adipokines), the inflammatory regulator interleukin-6 (IL-6) has emerged as one of the potential mediators that link obesity-derived chronic inflammation with insulin resistance. Adipose tissue contributes to up to 35% of circulating IL-6, the systemic effects of which have been best demonstrated in the liver, where a STAT3-SOCS-3 pathway mediates IL-6 impairment of insulin actions. However, this cytokine displays pleiotropic functions in a tissue-specific and physiological context-dependent manner. In contrast to its role in liver, IL-6 is believed to be beneficial for insulin-regulated glucose metabolism in muscle. Furthermore, the effects of the cytokine are seemingly influenced by whether it is present acutely or chronically; the latter is the setting associated with insulin resistance. Herein we review the in vivo and in vitro studies that have examined the role of IL-6 in insulin signaling and glucose metabolism in the insulin target tissues: liver, adipose, and skeletal muscle. | lld:pubmed |
| pubmed-article:19251052 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19251052 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19251052 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19251052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19251052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19251052 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19251052 | pubmed:issn | 0083-6729 | lld:pubmed |
| pubmed-article:19251052 | pubmed:author | pubmed-author:ChenJieJ | lld:pubmed |
| pubmed-article:19251052 | pubmed:author | pubmed-author:KimJeong-HoJH | lld:pubmed |
| pubmed-article:19251052 | pubmed:author | pubmed-author:BachmannRebec... | lld:pubmed |
| pubmed-article:19251052 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19251052 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:19251052 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19251052 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19251052 | pubmed:pagination | 613-33 | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:meshHeading | pubmed-meshheading:19251052... | lld:pubmed |
| pubmed-article:19251052 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19251052 | pubmed:articleTitle | Interleukin-6 and insulin resistance. | lld:pubmed |
| pubmed-article:19251052 | pubmed:affiliation | Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. | lld:pubmed |
| pubmed-article:19251052 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19251052 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:19251052 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19251052 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19251052 | lld:pubmed |
