| pubmed-article:19237651 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0014383 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19237651 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19237651 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19237651 | pubmed:dateCreated | 2009-4-27 | lld:pubmed |
| pubmed-article:19237651 | pubmed:abstractText | A novel compound, TTP-8307, was identified as a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits viral RNA synthesis in a dose-dependent manner, without affecting polyprotein synthesis and/or processing. Drug-resistant variants of coxsackievirus B3 were all shown to carry at least one amino acid mutation in the nonstructural protein 3A. In particular, three mutations located in a nonstructured region preceding the hydrophobic domain (V45A, I54F, and H57Y) appeared to contribute to the drug-resistant phenotype. This region has previously been identified as a hot sport for mutations that resulted in resistance to enviroxime, the sole 3A-targeting enterovirus inhibitor reported thus far. This was corroborated by the fact that TTP-8307 and enviroxime proved cross-resistant. It is hypothesized that TTP-8307 and enviroxime disrupt proper interactions of 3A(B) with other viral or cellular proteins that are required for efficient replication. | lld:pubmed |
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| pubmed-article:19237651 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19237651 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19237651 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19237651 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19237651 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19237651 | pubmed:month | May | lld:pubmed |
| pubmed-article:19237651 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:NeytsJohanJ | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:AndrewsRobert... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:LankeKjerstin... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:HeggermontWar... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:ThibautHendri... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:IrelandStephe... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:ArimilliMurty... | lld:pubmed |
| pubmed-article:19237651 | pubmed:author | pubmed-author:Al-TelTaleb... | lld:pubmed |
| pubmed-article:19237651 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19237651 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:19237651 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19237651 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19237651 | pubmed:pagination | 1850-7 | lld:pubmed |
| pubmed-article:19237651 | pubmed:dateRevised | 2010-9-22 | lld:pubmed |
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