Source:http://linkedlifedata.com/resource/pubmed/id/19234151
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-2-23
|
| pubmed:abstractText |
Foxp3 is a transcription factor that is essential for the normal development of regulatory T cells (Tregs). In the absence of microRNAs (miRNAs), Foxp3(+) Tregs develop but fail to maintain immune homeostasis, leading to a scurfy-like disease. Global analysis of the network of genes regulated by Foxp3 has identified the miRNA miR-155, which is highly expressed in Tregs, as a direct target of Foxp3. In this study we report that miR-155-deficient mice have reduced numbers of Tregs, both in the thymus and periphery, due to impaired development. However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1550-6606
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
182
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2578-82
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| pubmed:meshHeading |
pubmed-meshheading:19234151-Adoptive Transfer,
pubmed-meshheading:19234151-Animals,
pubmed-meshheading:19234151-CD4 Lymphocyte Count,
pubmed-meshheading:19234151-Cell Differentiation,
pubmed-meshheading:19234151-Cell Lineage,
pubmed-meshheading:19234151-Cell Proliferation,
pubmed-meshheading:19234151-Cell Survival,
pubmed-meshheading:19234151-Colitis,
pubmed-meshheading:19234151-Forkhead Transcription Factors,
pubmed-meshheading:19234151-Inflammatory Bowel Diseases,
pubmed-meshheading:19234151-Lymphopenia,
pubmed-meshheading:19234151-Mice,
pubmed-meshheading:19234151-Mice, Inbred C57BL,
pubmed-meshheading:19234151-Mice, Knockout,
pubmed-meshheading:19234151-MicroRNAs,
pubmed-meshheading:19234151-Spleen,
pubmed-meshheading:19234151-T-Lymphocytes, Regulatory,
pubmed-meshheading:19234151-Thymus Gland
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.
|
| pubmed:affiliation |
Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|