Source:http://linkedlifedata.com/resource/pubmed/id/19216081
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
Amino acid syn-1-amino-3-fluoro-cyclobutyl-1-carboxylic acid (syn-FACBC) 12, the isomer of anti-FACBC, has been selectively synthesized and [(18)F] radiofluorinated in 52% decay-corrected yield using no-carrier-added [(18)F]fluoride. The key step in the synthesis of the desired isomer involved stereoselective reduction using lithium alkylborohydride/zinc chloride, which improved the ratio of anti-alcohol to syn-alcohol from 17:83 to 97:3. syn-FACBC 12 entered rat 9L gliosarcoma cells primarily via L-type amino acid transport in vitro with high uptake of 16% injected dose per 5 x 10(5) cells. Biodistribution studies in rats with 9L gliosarcoma brain tumors demonstrated high tumor to brain ratio of 12:1 at 30 min post injection. In this model, amino acid syn-[(18)F]FACBC 12 is a promising metabolically based radiotracer for positron emission tomography brain tumor imaging.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1982-90
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pubmed:meshHeading |
pubmed-meshheading:19216081-Amino Acids,
pubmed-meshheading:19216081-Animals,
pubmed-meshheading:19216081-Brain Neoplasms,
pubmed-meshheading:19216081-Carboxylic Acids,
pubmed-meshheading:19216081-Cell Line, Tumor,
pubmed-meshheading:19216081-Isotope Labeling,
pubmed-meshheading:19216081-Octanes,
pubmed-meshheading:19216081-Positron-Emission Tomography,
pubmed-meshheading:19216081-Radiopharmaceuticals,
pubmed-meshheading:19216081-Rats,
pubmed-meshheading:19216081-Stereoisomerism
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pubmed:year |
2009
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pubmed:articleTitle |
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
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pubmed:affiliation |
Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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