Linked Life Data

19213048

Source:http://linkedlifedata.com/resource/pubmed/id/19213048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-7-8
pubmed:abstractText
The failure of artificial vascular grafts in small diameter vessel replacement is mainly due to the early formation of thrombosis. To prevent the occurrence of thrombosis, much effort has been focused on developing an anti-thrombogenic coating of synthetic vascular prostheses or artificial conduits with improved anti-thrombogenic properties. Because surface coatings may be unstable for long-term applications, a bulk material with anti-thrombogenic property is desirable for the fabrication of vascular grafts or conduits. To this end, we have chemically modified chitosan by phthalization to derive an anti-thrombogenic material for the fabrication of vascular grafts. The chemical structure of phthalized chitosan was characterized with infrared spectroscopy. The hydrophilicity was examined with contact angle measurement, and the molecular weight distribution was measured using gel permeation chromatography (GPC). Protein adsorption, hemolysis, and platelet adhesion assays were used to confirm the enhanced anti-thrombogenic properties of this phthalized chitosan. Cytotoxicity and proliferation assays were performed to test its high biocompatibility. With its improved solubility and processibility, this phthalized chitosan was fabricated into selective permeable tubular constructs of varying sizes and morphology through a wet phase-inversion process. With improved anti-thrombogenic property, biocompatibility, and great processibility, phthalized chitosan has great potential as the material for the fabrication of small diameter vascular grafts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1552-4981
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
668-78
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Fabrication of permeable tubular constructs from chemically modified chitosan with enhanced antithrombogenic property.
pubmed:affiliation
Clemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, South Carolina 29425, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural