| pubmed-article:19179282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C1540661 | lld:lifeskim |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C1257851 | lld:lifeskim |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C1609990 | lld:lifeskim |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:19179282 | lifeskim:mentions | umls-concept:C0439534 | lld:lifeskim |
| pubmed-article:19179282 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19179282 | pubmed:dateCreated | 2009-2-19 | lld:pubmed |
| pubmed-article:19179282 | pubmed:abstractText | Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, we demonstrate such paths by controlling only the nanotopography of culture substrates. Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media. hMSC behavior in response to defined nanotube sizes revealed a very dramatic change in hMSC behavior in a relatively narrow range of nanotube dimensions. Small (approximately 30-nm diameter) nanotubes promoted adhesion without noticeable differentiation, whereas larger (approximately 70- to 100-nm diameter) nanotubes elicited a dramatic stem cell elongation (approximately 10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for unique orthopedics-related hMSC treatments. | lld:pubmed |
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| pubmed-article:19179282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19179282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19179282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19179282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19179282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19179282 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19179282 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:ChienShuS | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:EnglerAdam... | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:JinSunghoS | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:OhSeunghanS | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:BrammerKarla... | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:TengDayuD | lld:pubmed |
| pubmed-article:19179282 | pubmed:author | pubmed-author:LiY S JulieYS | lld:pubmed |
| pubmed-article:19179282 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19179282 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:19179282 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19179282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19179282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19179282 | pubmed:pagination | 2130-5 | lld:pubmed |
| pubmed-article:19179282 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19179282 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19179282 | pubmed:articleTitle | Stem cell fate dictated solely by altered nanotube dimension. | lld:pubmed |
| pubmed-article:19179282 | pubmed:affiliation | Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA. | lld:pubmed |
| pubmed-article:19179282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19179282 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19179282 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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