Linked Life Data

19170614

Source:http://linkedlifedata.com/resource/pubmed/id/19170614

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-11
pubmed:abstractText
We show that nanowire field-effect transistor (NWFET) arrays fabricated on both planar and flexible polymeric substrates can be reproducibly interfaced with spontaneously beating embryonic chicken hearts in both planar and bent conformations. Simultaneous recordings from glass microelectrode and NWFET devices show that NWFET conductance variations are synchronized with the beating heart. The conductance change associated with beating can be tuned substantially by device sensitivity, although the voltage-calibrated signals, 4-6 mV, are relatively constant and typically larger than signals recorded by microelectrode arrays. Multiplexed recording from NWFET arrays yielded signal propagation times across the myocardium with high spatial resolution. The transparent and flexible NWFET chips also enable simultaneous electrical recording and optical registration of devices to heart surfaces in three-dimensional conformations not possible with planar microdevices. The capability of simultaneous optical imaging and electrical recording also could be used to register devices to a specific region of the myocardium at the cellular level, and more generally, NWFET arrays fabricated on increasingly flexible plastic and/or biopolymer substrates have the potential to become unique tools for electrical recording from other tissue/organ samples or as powerful implants.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-12051313, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-14976402, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-15242982, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-15534818, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-16132132, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-16170313, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-16293749, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-16525764, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-16931757, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-17027251, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-17266383, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-17268465, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-1775376, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-17972939, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-17994251, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170614-18263708
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1530-6984
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
914-8
pubmed:dateRevised
2011-6-14
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Electrical recording from hearts with flexible nanowire device arrays.
pubmed:affiliation
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural