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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-2-6
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pubmed:abstractText |
Argonaute (Ago) proteins interact with small regulatory RNAs to mediate gene regulatory pathways. A recent report by Kiriakidou et al. 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). In a cap-bound eIF4E structure, two important aromatic residues of the motif stack on either side of a 7-methylguanosine 5'-triphosphate (m7Gppp) base. The corresponding Ago2 aromatic residues (F450 and F505) were hypothesized to perform the same cap-binding function. However, the detected similarity between the MC sequence and the eIF4E cap-binding motif was questionable.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19159466-10980157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19159466-11050429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19159466-11790254,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19159466-9927721
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1745-6150
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19159466-Amino Acid Sequence,
pubmed-meshheading:19159466-Animals,
pubmed-meshheading:19159466-Argonaute Proteins,
pubmed-meshheading:19159466-Binding Sites,
pubmed-meshheading:19159466-Computational Biology,
pubmed-meshheading:19159466-Conserved Sequence,
pubmed-meshheading:19159466-Eukaryotic Initiation Factor-2,
pubmed-meshheading:19159466-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:19159466-Humans,
pubmed-meshheading:19159466-Models, Molecular,
pubmed-meshheading:19159466-Molecular Sequence Data,
pubmed-meshheading:19159466-Protein Structure, Tertiary,
pubmed-meshheading:19159466-RNA, Messenger,
pubmed-meshheading:19159466-RNA Caps,
pubmed-meshheading:19159466-Sequence Alignment
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pubmed:year |
2009
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pubmed:articleTitle |
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.
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pubmed:affiliation |
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA. lkinch@chop.swmed.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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