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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018801,
umls-concept:C0026809,
umls-concept:C0027051,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0205179,
umls-concept:C0205217,
umls-concept:C0600519,
umls-concept:C0757672,
umls-concept:C1522565,
umls-concept:C1880177,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-27
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pubmed:abstractText |
Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role in left ventricular (LV) failure remains incompletely understood. We therefore measured LV PDE5 expression in patients with advanced systolic heart failure and characterized LV remodeling after myocardial infarction in transgenic mice with cardiomyocyte-specific overexpression of PDE5 (PDE5-TG).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BiesmansLiesbethL,
pubmed-author:BitoVirginieV,
pubmed-author:BlochKenneth DKD,
pubmed-author:BuschCorneliusC,
pubmed-author:BuysEmmanuelE,
pubmed-author:GheysensOlivierO,
pubmed-author:GillijnsHildeH,
pubmed-author:HerijgersPaulP,
pubmed-author:JanssensStefan PSP,
pubmed-author:LenaertsIlseI,
pubmed-author:LiuXiaoshunX,
pubmed-author:MarsboomGlennG,
pubmed-author:PellensMarijkeM,
pubmed-author:PokreiszPeterP,
pubmed-author:SchoonjansLucL,
pubmed-author:SipidoKarinK,
pubmed-author:Van LommelAlfonsA,
pubmed-author:Van den BerghAnA,
pubmed-author:VandenwijngaertSaraS,
pubmed-author:VanhaeckeJohanJ,
pubmed-author:VerbekenErikE,
pubmed-author:VermeerschPieterP
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
408-16
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pubmed:dateRevised |
2009-10-14
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pubmed:meshHeading |
pubmed-meshheading:19139381-Animals,
pubmed-meshheading:19139381-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:19139381-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:19139381-Heart Failure,
pubmed-meshheading:19139381-Heart Ventricles,
pubmed-meshheading:19139381-Humans,
pubmed-meshheading:19139381-Mice,
pubmed-meshheading:19139381-Mice, Inbred C57BL,
pubmed-meshheading:19139381-Mice, Transgenic,
pubmed-meshheading:19139381-Myocardial Infarction,
pubmed-meshheading:19139381-Myocardium,
pubmed-meshheading:19139381-Ventricular Remodeling
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pubmed:year |
2009
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pubmed:articleTitle |
Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice.
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pubmed:affiliation |
Vesalius Research Center, Flanders Institute for Biotechnology, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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