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pubmed-article:19121588pubmed:abstractTextFollowing partial meniscectomy, the remaining meniscus is exposed to an altered loading environment. In vitro 20% dynamic compressive strains on meniscal tissue explants has been shown to lead to an increase in release of glycosaminoglycans from the tissue and increased expression of interleukin-1alpha (IL-1alpha). The goal of this study was to determine if compressive loading which induces endogenously expressed IL-1 results in downstream changes in gene expression of anabolic and catabolic molecules in meniscal tissue, such as MMP expression.lld:pubmed
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pubmed-article:19121588pubmed:articleTitleMeniscal tissue explants response depends on level of dynamic compressive strain.lld:pubmed
pubmed-article:19121588pubmed:affiliationBiotechnology Research Center, Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, United States.lld:pubmed
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