Source:http://linkedlifedata.com/resource/pubmed/id/19121588
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-5-20
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pubmed:abstractText |
Following partial meniscectomy, the remaining meniscus is exposed to an altered loading environment. In vitro 20% dynamic compressive strains on meniscal tissue explants has been shown to lead to an increase in release of glycosaminoglycans from the tissue and increased expression of interleukin-1alpha (IL-1alpha). The goal of this study was to determine if compressive loading which induces endogenously expressed IL-1 results in downstream changes in gene expression of anabolic and catabolic molecules in meniscal tissue, such as MMP expression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1522-9653
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
754-60
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pubmed:meshHeading |
pubmed-meshheading:19121588-Animals,
pubmed-meshheading:19121588-Collagenases,
pubmed-meshheading:19121588-Compressive Strength,
pubmed-meshheading:19121588-Gene Expression,
pubmed-meshheading:19121588-Knee Joint,
pubmed-meshheading:19121588-Menisci, Tibial,
pubmed-meshheading:19121588-Osteoarthritis, Knee,
pubmed-meshheading:19121588-Stress, Mechanical,
pubmed-meshheading:19121588-Swine,
pubmed-meshheading:19121588-Up-Regulation,
pubmed-meshheading:19121588-Weight-Bearing
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pubmed:year |
2009
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pubmed:articleTitle |
Meniscal tissue explants response depends on level of dynamic compressive strain.
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pubmed:affiliation |
Biotechnology Research Center, Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, United States.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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