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19097784
Source:
http://linkedlifedata.com/resource/pubmed/id/19097784
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0243077
,
umls-concept:C0290178
,
umls-concept:C0599532
,
umls-concept:C1335227
,
umls-concept:C1880355
pubmed:issue
3
pubmed:dateCreated
2009-1-27
pubmed:abstractText
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases
,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes
,
http://linkedlifedata.com/resource/pubmed/chemical/polo-like kinase 1
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1464-3405
pubmed:author
pubmed-author:AndrewsC WebbCW
,
pubmed-author:BadiangJennifer GJG
,
pubmed-author:CheungMuiM
,
pubmed-author:Davis-WardRonda GRG
,
pubmed-author:DicksonHamilton DHD
,
pubmed-author:DrewryDavid HDH
,
pubmed-author:EmersonHolly KHK
,
pubmed-author:EmmitteKyle AKA
,
pubmed-author:EpperlyAndrea HAH
,
pubmed-author:HasslerDaniel FDF
,
pubmed-author:KnickVictoria BVB
,
pubmed-author:KuntzKevin WKW
,
pubmed-author:LansingTimothy JTJ
,
pubmed-author:LinnJames AJA
,
pubmed-author:MookRobert ARAJr
,
pubmed-author:NailorKristen EKE
,
pubmed-author:SalovichJames MJM
,
pubmed-author:SpeharGlenn MGM
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1018-21
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:19097784-Animals
,
pubmed-meshheading:19097784-Cell Cycle
,
pubmed-meshheading:19097784-Cell Cycle Proteins
,
pubmed-meshheading:19097784-Cell Line, Tumor
,
pubmed-meshheading:19097784-Cell Proliferation
,
pubmed-meshheading:19097784-Chemistry, Pharmaceutical
,
pubmed-meshheading:19097784-Drug Design
,
pubmed-meshheading:19097784-Enzyme Inhibitors
,
pubmed-meshheading:19097784-Humans
,
pubmed-meshheading:19097784-Inhibitory Concentration 50
,
pubmed-meshheading:19097784-Mice
,
pubmed-meshheading:19097784-Mitosis
,
pubmed-meshheading:19097784-Models, Chemical
,
pubmed-meshheading:19097784-Molecular Conformation
,
pubmed-meshheading:19097784-Protein-Serine-Threonine Kinases
,
pubmed-meshheading:19097784-Proto-Oncogene Proteins
,
pubmed-meshheading:19097784-Thiophenes
pubmed:year
2009
pubmed:articleTitle
Discovery of thiophene inhibitors of polo-like kinase.
pubmed:affiliation
Oncology R & D, GlaxoSmithKline, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA. kyle.a.emmitte@Vanderbilt.edu
pubmed:publicationType
Journal Article