Linked Life Data

19081221

Source:http://linkedlifedata.com/resource/pubmed/id/19081221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-9
pubmed:abstractText
Since urine contains thousands of metabolites, there are no universal analytical techniques to analyze these compounds simultaneously. Therefore, a readily obtained and simple sample pretreatment high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection urinary profiling with good reproducibility was developed for metabonomic study in this paper. The results of current study clearly showed that there were different phenotypes of metabolites based on HPLC-UV urinary profiling after administration of Liuwei Dihuang Pills (LWPs) or Carrageenan-stimulated inflammation model, and those could be conveniently discriminated by principal component analysis (PCA). In addition, the results also showed that LWPs could restore the metabolite network that disturbed by inflammation, which would be a proof of therapeutic efficacy of LWPs to inflammation by metabonomics study. Our study indicated that HPLC-UV method could be used as a potentially powerful tool for urinary profiling on metabonomic studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
492-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Development of rat urinary HPLC-UV profiling for metabonomic study on Liuwei Dihuang Pills.
pubmed:affiliation
West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China.
pubmed:publicationType
Journal Article