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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-26
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pubmed:abstractText |
A series of alpha-amidosulfones were found to be potent and selective agonists of CB(2). The discovery, synthesis, and structure-activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ChengAlanA,
pubmed-author:DiMauroErin FEF,
pubmed-author:EmkeyReneeR,
pubmed-author:FremeauRobert TRTJr,
pubmed-author:HitchcockStephen ASA,
pubmed-author:HuangLiyueL,
pubmed-author:HuangMing YMY,
pubmed-author:HumanJasonJ,
pubmed-author:LeeJosie HJH,
pubmed-author:LiXingwenX,
pubmed-author:MartinMatthew WMW,
pubmed-author:MarxIsaac EIE,
pubmed-author:PatelVinod FVF,
pubmed-author:WhiteRyan DRD
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-5
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pubmed:meshHeading |
pubmed-meshheading:19062274-Amides,
pubmed-meshheading:19062274-Animals,
pubmed-meshheading:19062274-Humans,
pubmed-meshheading:19062274-Microsomes, Liver,
pubmed-meshheading:19062274-Pharmacokinetics,
pubmed-meshheading:19062274-Rats,
pubmed-meshheading:19062274-Receptor, Cannabinoid, CB2,
pubmed-meshheading:19062274-Structure-Activity Relationship,
pubmed-meshheading:19062274-Sulfones
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pubmed:year |
2009
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pubmed:articleTitle |
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
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pubmed:affiliation |
Department of Medicinal Chemistry, Amgen Inc, One Kendall Square, Cambridge, MA 02139, USA. imarx@amgen.com
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pubmed:publicationType |
Journal Article
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