Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-8-15
|
| pubmed:abstractText |
The effects of the water-insoluble fraction of mouse seminal vesicle fluid (WIF-SVF) on lymphocytes was investigated to clarify its role in reproductive immunity. WIF-SVF inhibited the blastogenic response of T-cells to concanavalin-A (Con-A), but it did not inhibit the blastogenic response of B-cells to lipopolysaccharide (LPS). Pretreatment of splenocytes with WIF-SVF did not suppress the blastogenic response of splenocytes to Con-A when treated cells were washed prior to culture. WIF-SVF did not inhibit the proliferation of Con-A activated splenocytes, the response of listeria-immune splenocytes to listerial antigen, or the proliferation of IL 2-dependent HT-2 cells, or the growth of tumour cells (Yac 1 cells, Ehrlich ascites carcinoma cells, EL-4 cells). A listerial antigen-specific immune response was not induced after mice were immunized with both listerial antigen and WIF-SVF. WIF-SVF is mainly composed of protein and its suppressive activity was enhanced by heating at 100 degrees C. These results suggest that WIF-SVF inhibits the responsiveness of T-cells to antigens or mitogens non-specifically at the initial stage.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0105-6263
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
196-208
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:1906049-Animals,
pubmed-meshheading:1906049-Body Fluids,
pubmed-meshheading:1906049-Cells, Cultured,
pubmed-meshheading:1906049-Concanavalin A,
pubmed-meshheading:1906049-Hot Temperature,
pubmed-meshheading:1906049-Immune Tolerance,
pubmed-meshheading:1906049-Immunization,
pubmed-meshheading:1906049-Interleukin-2,
pubmed-meshheading:1906049-Listeria monocytogenes,
pubmed-meshheading:1906049-Lymphocyte Activation,
pubmed-meshheading:1906049-Male,
pubmed-meshheading:1906049-Mice,
pubmed-meshheading:1906049-Mice, Inbred Strains,
pubmed-meshheading:1906049-Seminal Vesicles,
pubmed-meshheading:1906049-Solubility,
pubmed-meshheading:1906049-Spleen,
pubmed-meshheading:1906049-T-Lymphocytes,
pubmed-meshheading:1906049-Tumor Cells, Cultured
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Biological functions of the water-insoluble fraction of mouse seminal vesicle fluid. I. Suppression of the blastogenic response of lymphocytes.
|
| pubmed:affiliation |
Department of Bacteriology, Nara Medical University, Japan.
|
| pubmed:publicationType |
Journal Article
|