| pubmed-article:19055482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0042774 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C2607512 | lld:lifeskim |
| pubmed-article:19055482 | lifeskim:mentions | umls-concept:C1699868 | lld:lifeskim |
| pubmed-article:19055482 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19055482 | pubmed:dateCreated | 2009-1-2 | lld:pubmed |
| pubmed-article:19055482 | pubmed:abstractText | 4'-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several derivatives of 4'-azidocytidine by varying the substituents at the ribose 2' and 3'-positions. The most potent compound in this series is 4'-azidoarabinocytidine with an IC(50) of 0.17 microM in the genotype 1b subgenomic replicon system. The structure-activity relationships within this series of nucleoside analogues are discussed. | lld:pubmed |
| pubmed-article:19055482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19055482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19055482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19055482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19055482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19055482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19055482 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19055482 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:SmithMarkM | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:CammackNickN | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:BenkestockKur... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:ZhouXiao-Xion... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:PinhoPedroP | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:KlumppKlausK | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:MartinJoseph... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:SmithDavid... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:HoltLisaL | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:RajyaguruSona... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:MaltsevaTatia... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:LevequeVincen... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:KalayanovGena... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:JohanssonNils... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:SwallowSteven... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:NajeraIsabelI | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:SundChristian... | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:WinqvistAnnaA | lld:pubmed |
| pubmed-article:19055482 | pubmed:author | pubmed-author:MorissonVeron... | lld:pubmed |
| pubmed-article:19055482 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19055482 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:19055482 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19055482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19055482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19055482 | pubmed:pagination | 219-23 | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:meshHeading | pubmed-meshheading:19055482... | lld:pubmed |
| pubmed-article:19055482 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19055482 | pubmed:articleTitle | The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. | lld:pubmed |
| pubmed-article:19055482 | pubmed:affiliation | Roche Palo Alto LLC, Palo Alto, California 94304, USA. | lld:pubmed |
| pubmed-article:19055482 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19055482 | lld:chembl |
