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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-3
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pubmed:abstractText |
Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long-term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic-induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as beta-arrestin 2 (ARRB2), an important mediator between DRD2 and serine-threonine protein kinase (AKT) signal cascade.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1468-1331
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1406-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19049562-Antipsychotic Agents,
pubmed-meshheading:19049562-Arrestins,
pubmed-meshheading:19049562-Asian Continental Ancestry Group,
pubmed-meshheading:19049562-Case-Control Studies,
pubmed-meshheading:19049562-DNA Mutational Analysis,
pubmed-meshheading:19049562-Dyskinesia, Drug-Induced,
pubmed-meshheading:19049562-Female,
pubmed-meshheading:19049562-Genetic Markers,
pubmed-meshheading:19049562-Genetic Predisposition to Disease,
pubmed-meshheading:19049562-Genetic Testing,
pubmed-meshheading:19049562-Humans,
pubmed-meshheading:19049562-Male,
pubmed-meshheading:19049562-Open Reading Frames,
pubmed-meshheading:19049562-Polymorphism, Genetic,
pubmed-meshheading:19049562-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19049562-Receptors, Dopamine D2,
pubmed-meshheading:19049562-Schizophrenia,
pubmed-meshheading:19049562-Signal Transduction,
pubmed-meshheading:19049562-Taiwan
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pubmed:year |
2008
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pubmed:articleTitle |
The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.
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pubmed:affiliation |
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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