| pubmed-article:19048294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C0025485 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C0205131 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C0026559 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C1416658 | lld:lifeskim |
| pubmed-article:19048294 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:19048294 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19048294 | pubmed:dateCreated | 2009-1-26 | lld:pubmed |
| pubmed-article:19048294 | pubmed:abstractText | We have previously isolated a cDNA clone coding for Xenopus AP-2rep (activator protein-2 repressor), a member of the Krüppel-like factor family, and reported its expression pattern in developing Xenopus embryos. In the present study, the physiological function of AP-2rep in the morphogenetic movements of the dorsal mesoderm and ectoderm was investigated. Embryos injected with either AP-2rep or VP16repC (a dominant-negative mutant) into the dorsal marginal zone at the 4-cell stage exhibited abnormal morphology in dorsal structures. Both AP-2rep and VP16repC also inhibited the elongation of animal cap explants treated with activin without affecting the expression of differentiation markers. Whole-mount in situ hybridization analysis revealed that expression of brachyury and Wnt11 was greatly suppressed by injection of VP16repC or AP-2rep morpholino, but expression was restored by the simultaneous injection of wild-type AP-2rep RNA. Furthermore, the morphogenetic abnormality induced by injection of VP16repC or AP-2rep morpholino was restored by simultaneous injection of brachyury or Wnt11 mRNA. These results show that AP-2rep is involved in the morphogenesis of the mesoderm at the gastrula stage, via the brachyury and/or Wnt pathways. | lld:pubmed |
| pubmed-article:19048294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19048294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19048294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19048294 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19048294 | pubmed:issn | 1432-0878 | lld:pubmed |
| pubmed-article:19048294 | pubmed:author | pubmed-author:GotohMasanori... | lld:pubmed |
| pubmed-article:19048294 | pubmed:author | pubmed-author:SaitoYoshinar... | lld:pubmed |
| pubmed-article:19048294 | pubmed:author | pubmed-author:IzutsuYumiY | lld:pubmed |
| pubmed-article:19048294 | pubmed:author | pubmed-author:MaénoMitsuguM | lld:pubmed |
| pubmed-article:19048294 | pubmed:author | pubmed-author:UjiieYasutaka... | lld:pubmed |
| pubmed-article:19048294 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19048294 | pubmed:volume | 335 | lld:pubmed |
| pubmed-article:19048294 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19048294 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19048294 | pubmed:pagination | 357-69 | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
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| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:meshHeading | pubmed-meshheading:19048294... | lld:pubmed |
| pubmed-article:19048294 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19048294 | pubmed:articleTitle | Involvement of AP-2rep in morphogenesis of the axial mesoderm in Xenopus embryo. | lld:pubmed |
| pubmed-article:19048294 | pubmed:affiliation | Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata, Japan. | lld:pubmed |
| pubmed-article:19048294 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19048294 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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