Linked Life Data

19035764

Source:http://linkedlifedata.com/resource/pubmed/id/19035764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-29
pubmed:abstractText
Ru(II) complexes possessing new tridentate ligands with extended pi systems, pydppx (3-(pyrid-2'-yl)-11,12-dimethyl-dipyrido[3,2-a:2',3'-c]phenazine) and pydppn (3-(pyrid-2'-yl)-4,5,9,16-tetraaza-dibenzo[a,c]naphthacene), were synthesized and characterized. The investigation of the photophysical properties of the series [Ru(tpy)(n)(L)(2-n)](2+) (L = pydppx, pydppn, n = 0-2) reveals markedly different excited state behavior among the complexes. The Ru(II) complexes possessing the pydppx ligand are similar to the pydppz (3-(pyrid-2'-yl)dipyrido[3,2-a:2',3'-c]phenazine) systems, with a lowest energy metal-to-ligand charge transfer excited state with lifetimes of 1-4 ns. In contrast, the lowest energy excited state in the [Ru(tpy)(n)(pydppn)(2-n)](2+) (n = 0, 1) complexes is a ligand-centered (3)pipi* localized on the pydppn ligand with lifetimes of approximately 20 mus. The [Ru(tpy)(n)(pydppn)(2-n)](2+) (n = 0, 1) complexes are able to generate (1)O(2) with approximately 100% efficiency. Both [Ru(tpy)(pydppn)](2+) and [Ru(pydppn)(2)](2+) bind to DNA, however, the former exhibits a approximately 10-fold greater DNA binding constant than the latter. Efficient DNA photocleavage is observed for [Ru(tpy)(pydppn)](2+), owing to its ability to photosensitize the production of (1)O(2), which can mediate the reactivity. Such high quantum yields of (1)O(2) photosensitization of transition metal complexes may be useful in the design of new systems with long-lived excited states for photodynamic therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1520-510X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-85
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Ru(II) complexes of new tridentate ligands: unexpected high yield of sensitized 1O2.
pubmed:affiliation
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't