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pubmed-article:19023560pubmed:abstractTextThe enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical. This notion has been addressed in different lines of HSL knockout mice with contradictory results.lld:pubmed
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pubmed-article:19023560pubmed:articleTitleA beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.lld:pubmed
pubmed-article:19023560pubmed:affiliationDepartment of Clinical Sciences, Clinical Research Centre , Malmö University Hospital (UMAS), Malmö, Sweden. malin.fex@med.lu.selld:pubmed
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