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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-9
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pubmed:abstractText |
The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical. This notion has been addressed in different lines of HSL knockout mice with contradictory results.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1432-0428
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pubmed:author |
pubmed-author:Dekker-NitertMM,
pubmed-author:EliassonLL,
pubmed-author:GER,
pubmed-author:HaemmerliCC,
pubmed-author:HoltDD,
pubmed-author:MulderHH,
pubmed-author:RehrII,
pubmed-author:RistowMM,
pubmed-author:SundlerFF,
pubmed-author:WierumCC,
pubmed-author:ZechnerRR
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-80
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19023560-Adipose Tissue,
pubmed-meshheading:19023560-Animals,
pubmed-meshheading:19023560-Area Under Curve,
pubmed-meshheading:19023560-Blood Glucose,
pubmed-meshheading:19023560-Exocytosis,
pubmed-meshheading:19023560-Exons,
pubmed-meshheading:19023560-Glucose Tolerance Test,
pubmed-meshheading:19023560-Hyperglycemia,
pubmed-meshheading:19023560-Insulin,
pubmed-meshheading:19023560-Insulin-Secreting Cells,
pubmed-meshheading:19023560-Mice,
pubmed-meshheading:19023560-Mice, Inbred C57BL,
pubmed-meshheading:19023560-Mice, Knockout,
pubmed-meshheading:19023560-Mutation,
pubmed-meshheading:19023560-Polymerase Chain Reaction,
pubmed-meshheading:19023560-RNA, Messenger,
pubmed-meshheading:19023560-Secretory Vesicles,
pubmed-meshheading:19023560-Sterol Esterase
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pubmed:year |
2009
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pubmed:articleTitle |
A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.
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pubmed:affiliation |
Department of Clinical Sciences, Clinical Research Centre , Malmö University Hospital (UMAS), Malmö, Sweden. malin.fex@med.lu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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