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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-2-25
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pubmed:abstractText |
Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-1968289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-1971916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-1972161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-1976282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2466082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2531192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2531293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2538552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2647894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2950524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2955418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-2955518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-323401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1899105-3471350
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1899105-Animals,
pubmed-meshheading:1899105-Antibodies, Monoclonal,
pubmed-meshheading:1899105-Antigens, CD4,
pubmed-meshheading:1899105-Antigens, CD8,
pubmed-meshheading:1899105-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1899105-Graft Survival,
pubmed-meshheading:1899105-Immune Tolerance,
pubmed-meshheading:1899105-Islets of Langerhans Transplantation,
pubmed-meshheading:1899105-Lymphocyte Activation,
pubmed-meshheading:1899105-Male,
pubmed-meshheading:1899105-Mice,
pubmed-meshheading:1899105-Mice, Inbred A,
pubmed-meshheading:1899105-Mice, Inbred C57BL,
pubmed-meshheading:1899105-Receptors, Antigen, T-Cell,
pubmed-meshheading:1899105-T-Lymphocyte Subsets
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pubmed:year |
1991
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pubmed:articleTitle |
Anti-CD4 mediates clonal anergy during transplantation tolerance induction.
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pubmed:affiliation |
Department of Medicine, Stanford University School of Medicine, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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