Source:http://linkedlifedata.com/resource/pubmed/id/18949449
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2008-12-10
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| pubmed:abstractText |
The eradication of Helicobacter pylori (H. pylori) with antibiotics induces complete remission in 75% of patients with gastric MALT lymphoma. We investigated the efficacy of H. pylori eradication and assessed the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) patients from mainland China. Twenty-two gastric MALT cases (Stage I(E)) underwent H. pylori eradication with antibiotics, and sequential endoscopic-bioptic follow-ups were performed and assessed with regular morphologic and immunohistochemical examinations. BCL10 nuclear expression and interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 were tested. Thirteen out of the 22 cases (59.1%) achieved complete regression (CR) after the eradication of H. pylori. The longest follow-up period in the 22 patients was 68 months, with 12 patients longer than 24 months. For the 13 CR patients, the longest follow-up period after H. pylori eradication was 53 months, with 6 patients longer than 24 months. BCL10 nuclear expression was detected by immunohistochemical staining in 9 cases, including 7 (77.8%) of 9 cases who showed no response (NR) and 2 (15.4%) of 13 patients who achieved CR following eradication therapy (P < 0.05). t(11;18)(q21;q21) was evaluated by interphase FISH in 18 cases including 11 CR and 7 NR patients after H. pylori eradication. t(11;18)(q21;q21) was found in 4 (57.1%) of 7 patients who showed NR following H. pylori eradication, but one in 11 CR patients (P < 0.05). A total of 59.1% of patients with early gastric MALT lymphoma recruited in this study achieved CR after H. pylori eradication. BCL10 nuclear expression and t(11;18)(q21;q21)-positive gastric MALT lymphomas are likely to be related to a failure to respond to H. pylori eradication in Chinese patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
1865-3774
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| pubmed:author |
pubmed-author:DongGehongG,
pubmed-author:GaoZifenZ,
pubmed-author:GongLipingL,
pubmed-author:HuangXinX,
pubmed-author:HuangXuebiaoX,
pubmed-author:HuangYuanjieY,
pubmed-author:KoçLL,
pubmed-author:LiuCuilingC,
pubmed-author:ShiYunfeiY,
pubmed-author:YeHongtaoH,
pubmed-author:YinWenjuanW,
pubmed-author:ZhengJieJ
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
88
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
516-23
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| pubmed:meshHeading |
pubmed-meshheading:18949449-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18949449-Adolescent,
pubmed-meshheading:18949449-Adult,
pubmed-meshheading:18949449-Aged,
pubmed-meshheading:18949449-Anti-Bacterial Agents,
pubmed-meshheading:18949449-Asian Continental Ancestry Group,
pubmed-meshheading:18949449-China,
pubmed-meshheading:18949449-Chromosomes, Human, Pair 11,
pubmed-meshheading:18949449-Chromosomes, Human, Pair 18,
pubmed-meshheading:18949449-Female,
pubmed-meshheading:18949449-Follow-Up Studies,
pubmed-meshheading:18949449-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18949449-Helicobacter Infections,
pubmed-meshheading:18949449-Helicobacter pylori,
pubmed-meshheading:18949449-Humans,
pubmed-meshheading:18949449-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:18949449-Male,
pubmed-meshheading:18949449-Middle Aged,
pubmed-meshheading:18949449-Stomach Neoplasms,
pubmed-meshheading:18949449-Translocation, Genetic
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.
|
| pubmed:affiliation |
Department of Pathology, Peking University Health Science Center, Beijing, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|