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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-20
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pubmed:abstractText |
Type 3 long-QT syndrome (LQT-3) is caused by gain-of-function mutations in the SCN5A encoding the cardiac sodium channel. Familial atrial fibrillation (AF), previously considered a potassium channelopathy, has recently been related to sodium genetic variants, both in isolated forms and in patients with underlying heart disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1556-3871
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pubmed:author |
pubmed-author:BenitoBegoñaB,
pubmed-author:BerruezoAntonioA,
pubmed-author:BrugadaJosepJ,
pubmed-author:BrugadaPedroP,
pubmed-author:BrugadaRamonR,
pubmed-author:CincaJuanJ,
pubmed-author:FreixaXavierX,
pubmed-author:LizotteEricE,
pubmed-author:MontLluisL,
pubmed-author:PerichRosa MariaRM,
pubmed-author:TolosanaJosé MaríaJM
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1434-40
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:18929331-Adult,
pubmed-meshheading:18929331-Aged,
pubmed-meshheading:18929331-Anti-Arrhythmia Agents,
pubmed-meshheading:18929331-Atrial Fibrillation,
pubmed-meshheading:18929331-Child,
pubmed-meshheading:18929331-Child, Preschool,
pubmed-meshheading:18929331-Female,
pubmed-meshheading:18929331-Flecainide,
pubmed-meshheading:18929331-Genetic Predisposition to Disease,
pubmed-meshheading:18929331-Humans,
pubmed-meshheading:18929331-Long QT Syndrome,
pubmed-meshheading:18929331-Male,
pubmed-meshheading:18929331-Middle Aged,
pubmed-meshheading:18929331-Muscle Proteins,
pubmed-meshheading:18929331-Mutation,
pubmed-meshheading:18929331-Sodium Channels
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pubmed:year |
2008
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pubmed:articleTitle |
A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation.
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pubmed:affiliation |
Cardiovascular Genetics Center, Montreal Heart Institute, University of Montreal, Montreal, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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