| pubmed-article:18922975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0033572 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18922975 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18922975 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18922975 | pubmed:dateCreated | 2008-10-16 | lld:pubmed |
| pubmed-article:18922975 | pubmed:abstractText | Bone morphogenetic proteins (BMP) have been implicated in the development of bone metastases in prostate cancer. In this study, we investigated the role which BMP-9 played in prostate cancer and found that the expression of BMP-9 was decreased or absent in prostate cancer, particularly in the foci of higher grade disease. We further investigated the influence of BMP-9 on the biological behaviors of prostate cancer cells. The forced overexpression of BMP-9 prevented the in vitro growth, cell-matrix adhesion, invasion, and migration of prostate cancer cells. We also elucidated that BMP-9 induced apoptosis in PC-3 cells through the up-regulation of prostate apoptosis response-4. Among the receptors which have been implicated in the signaling of BMP-9, BMPR-IB and BMPR-II have also been implicated in the development and progression of prostate cancer. Knockdown of BMPR-IB or BMPR-II using respective hammerhead ribozyme transgenes could promote cell growth in vitro. We also found that BMPR-II is indispensable for the Smad-dependent signal transduction by BMP-9 in PC-3 cells, in which Smad-1 was phosphorylated and translocated from the cytoplasm into the nuclei. Taken together, BMP-9 inhibits the growth of prostate cancer cells due to the induced apoptosis, which is related to an up-regulation of prostate apoptosis response-4 through a Smad-dependent pathway. BMP-9 could also prevent the migration and invasiveness of prostate cancer. This suggests that BMP-9 may function as a tumor suppressor and apoptosis regulator in prostate cancer. | lld:pubmed |
| pubmed-article:18922975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18922975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922975 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18922975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18922975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18922975 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18922975 | pubmed:issn | 1541-7786 | lld:pubmed |
| pubmed-article:18922975 | pubmed:author | pubmed-author:JiangWen GWG | lld:pubmed |
| pubmed-article:18922975 | pubmed:author | pubmed-author:LinYeY | lld:pubmed |
| pubmed-article:18922975 | pubmed:author | pubmed-author:KynastonHowar... | lld:pubmed |
| pubmed-article:18922975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18922975 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:18922975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18922975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18922975 | pubmed:pagination | 1594-606 | lld:pubmed |
| pubmed-article:18922975 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18922975 | pubmed:meshHeading | pubmed-meshheading:18922975... | lld:pubmed |
| pubmed-article:18922975 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18922975 | pubmed:articleTitle | Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. | lld:pubmed |
| pubmed-article:18922975 | pubmed:affiliation | Metastasis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, United Kingdom. Yel@cf.ac.uk | lld:pubmed |
| pubmed-article:18922975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18922975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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