Source:http://linkedlifedata.com/resource/pubmed/id/18854779
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2008-10-15
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pubmed:abstractText |
High-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin (CTC) has been developed as a possible curative treatment modality in several solid tumours. However, a large interindividual variability in toxicity is encountered in high-dose chemotherapy. A priori identification of patients at risk for toxicity could be an attractive prospect. Genotyping of genes encoding drug-metabolising enzymes might provide such a tool.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1744-6872
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1009-15
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pubmed:meshHeading |
pubmed-meshheading:18854779-Adolescent,
pubmed-meshheading:18854779-Adult,
pubmed-meshheading:18854779-Carboplatin,
pubmed-meshheading:18854779-Cyclophosphamide,
pubmed-meshheading:18854779-Female,
pubmed-meshheading:18854779-Gene Frequency,
pubmed-meshheading:18854779-Genotype,
pubmed-meshheading:18854779-Humans,
pubmed-meshheading:18854779-Male,
pubmed-meshheading:18854779-Metabolic Detoxication, Drug,
pubmed-meshheading:18854779-Middle Aged,
pubmed-meshheading:18854779-Neoplasms,
pubmed-meshheading:18854779-Polymorphism, Single Nucleotide,
pubmed-meshheading:18854779-Thiotepa
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pubmed:year |
2008
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pubmed:articleTitle |
Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin.
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pubmed:affiliation |
Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, The Netherlands. Corine.Ekhart@slz.nl
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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