| pubmed-article:18824172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0151744 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0035126 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C1420280 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C1419030 | lld:lifeskim |
| pubmed-article:18824172 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:18824172 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18824172 | pubmed:dateCreated | 2008-11-17 | lld:pubmed |
| pubmed-article:18824172 | pubmed:abstractText | The specific role of TNF-alpha receptors I (TNFR-I, p55) and II (TNFR-II, p75) in myocardial ischemic injury remains unclear. Using genetically engineered mice, we examined the relative effects of TNF-alpha signaling via p55 and p75 in acute myocardial ischemia/reperfusion injury under basal conditions and in late preconditioning (PC). Wild-type (WT) (C57BL/6 and B6,129) mice and mice lacking TNF-alpha (TNF-alpha(-/-)), p55 (p55(-/-)), p75 (p75(-/-)), or both receptors (p55(-/-)/p75(-/-)) underwent 30 min of coronary occlusion and 24 h of reperfusion with or without six cycles of 4-min coronary occlusion/4-min reperfusion (O/R) 24 h earlier (ischemic PC). Six cycles of O/R reduced infarct size 24 h later in WT mice, indicating a late PC effect. This late PC-induced infarct-sparing effect was abolished not only in TNF-alpha(-/-) and p55(-/-)/p75(-/-) mice, but also in p55(-/-) and p75(-/-) mice, indicating that TNF-alpha signaling via both p55 and p75 is necessary for the development of protection. In nonpreconditioned TNF-alpha(-/-), p55(-/-)/p75(-/-), and p75(-/-) mice, infarct size was similar to strain-matched WT mice. In contrast, infarct size in nonpreconditioned p55(-/-) mice was reduced compared with nonpreconditioned WT mice. We conclude that (i) unopposed p75 signaling (in the absence of p55) reduces infarct size following acute ischemia/reperfusion injury in naive myocardium, whereas unopposed p55 signaling (in the absence of p75) has no effect; and (ii) the development of the infarct-sparing effects of the late phase of PC requires nonredundant signaling via both p55 and p75 receptors. These findings reveal a fundamental, heretofore unrecognized, difference between the two TNF-alpha receptors in the setting of myocardial ischemia/reperfusion injury: that is, both p55 and p75 are necessary for the development of protection during late PC, but only signaling via p75 is protective in nonpreconditioned myocardium. | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18824172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18824172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18824172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18824172 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18824172 | pubmed:issn | 1095-8584 | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:TangXian-Lian... | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:BolliRobertoR | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:GuoYiruY | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:DawnBuddhadeb... | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:RezazadehAras... | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:TiwariSumitS | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:HuntGregG | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:FlahertyMicha... | lld:pubmed |
| pubmed-article:18824172 | pubmed:author | pubmed-author:SanganalmathS... | lld:pubmed |
| pubmed-article:18824172 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18824172 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:18824172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18824172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18824172 | pubmed:pagination | 735-41 | lld:pubmed |
| pubmed-article:18824172 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
| pubmed-article:18824172 | pubmed:meshHeading | pubmed-meshheading:18824172... | lld:pubmed |
