| pubmed-article:18810483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0017067 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0014876 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:18810483 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:18810483 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18810483 | pubmed:dateCreated | 2008-12-23 | lld:pubmed |
| pubmed-article:18810483 | pubmed:abstractText | Intraganglionic laminar endings (IGLEs) represent the major vagal afferent terminals throughout the gut. Electrophysiological experiments revealed a modulatory role of ATP in the IGLE-mechanotransduction process and the P2X(2)-receptor has been described in IGLEs of mouse, rat and guinea pig. Another purinoceptor, the P2X(3)-receptor, was found in IGLEs of the rat esophagus. These findings prompted us to investigate occurrence and distribution of the P2X(3)-receptor in the mouse esophagus. Using multichannel immunofluorescence and confocal microscopy, P2X(3)-immunoreactivity (-iry) was found colocalized with the vesicular glutamate transporter 2 (VGLUT2), a specific marker for IGLEs, on average in three-fourths of esophageal IGLEs. The distribution of P2X(3) immunoreactive (-ir) IGLEs was similar to that of P2X(2)-iry and showed increasing numbers towards the abdominal esophagus. P2X(3)/P2X(2)-colocalization within IGLEs suggested the occurrence of heteromeric P2X(2/3) receptors. In contrast to the rat, where only a few P2X(3)-ir perikarya were described, P2X(3) stained perikarya in ~80% of myenteric ganglia in the mouse. Detailed analysis revealed P2X(3)-iry in subpopulations of nitrergic (nNOS) and cholinergic (ChAT) myenteric neurons and ganglionic neuropil of the mouse esophagus. We conclude that ATP might act as a neuromodulator in IGLEs via a (P2X(2))-P2X(3) receptor-mediated pathway especially in the abdominal portion of the mouse esophagus. | lld:pubmed |
| pubmed-article:18810483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18810483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18810483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18810483 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18810483 | pubmed:issn | 1432-119X | lld:pubmed |
| pubmed-article:18810483 | pubmed:author | pubmed-author:NeuhuberWinfr... | lld:pubmed |
| pubmed-article:18810483 | pubmed:author | pubmed-author:RaabMarionM | lld:pubmed |
| pubmed-article:18810483 | pubmed:author | pubmed-author:KestlerChrist... | lld:pubmed |
| pubmed-article:18810483 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18810483 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:18810483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18810483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18810483 | pubmed:pagination | 13-27 | lld:pubmed |
| pubmed-article:18810483 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:meshHeading | pubmed-meshheading:18810483... | lld:pubmed |
| pubmed-article:18810483 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18810483 | pubmed:articleTitle | Distribution of P2X(3) receptor immunoreactivity in myenteric ganglia of the mouse esophagus. | lld:pubmed |
| pubmed-article:18810483 | pubmed:affiliation | Institut für Anatomie, Lehrstuhl I, Universität Erlangen-Nürnberg, Krankenhausstr. 9, 91054 Erlangen, Germany. | lld:pubmed |
| pubmed-article:18810483 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18810483 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:228139 | entrezgene:pubmed | pubmed-article:18810483 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18810483 | lld:entrezgene |
