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pubmed:abstractText |
In diabetic cardiomyopathy, diastolic dysfunction results in part from sarcoplasmic reticulum abnormalities affecting both phospholamban and sarcoplasmic reticulum Ca2+ uptake (SERCA2a). Consequently, the positive lusitropic effect of beta-adrenoceptors stimulation could be altered, and beta3-adrenoceptor over-expression may play a role, as previously demonstrated with an altered positive inotropic effect. In this study, we tested the hypothesis that the beta-adrenergic positive lusitropic effect is altered in diabetic cardiomyopathy, and that beta3-adrenoceptor over-expression is involved.
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pubmed:affiliation |
Département d'Anesthésie-Réanimation, CHU Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, UMPC Univ. Paris, 75651 Paris cedex 13, France. julien.amour@psl.aphp.f
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