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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-10-30
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pubmed:abstractText |
Humoral circulating inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) can impair skeletal muscle contractility. Furthermore, TNF-alpha expression correlates with elevated levels of atrogin-like muscle-specific ubiquitin E3 ligases, which are presumed to mediate muscle protein breakdown and atrophy. However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1089-8638
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pubmed:author |
pubmed-author:AdamsVolkerV,
pubmed-author:GaschAlexanderA,
pubmed-author:GielenStephanS,
pubmed-author:HirnerStephanieS,
pubmed-author:KrohneChristianC,
pubmed-author:LabeitSiegfriedS,
pubmed-author:LinkeAxelA,
pubmed-author:MangnerNormanN,
pubmed-author:SchulerGerhardG,
pubmed-author:ThierseHermann-JosefHJ,
pubmed-author:WittChristian CCC
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
384
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-59
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18804115-Animals,
pubmed-meshheading:18804115-Cell Line,
pubmed-meshheading:18804115-Down-Regulation,
pubmed-meshheading:18804115-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:18804115-Immunoprecipitation,
pubmed-meshheading:18804115-Mice,
pubmed-meshheading:18804115-Models, Biological,
pubmed-meshheading:18804115-Muscle, Skeletal,
pubmed-meshheading:18804115-Muscle Contraction,
pubmed-meshheading:18804115-Muscle Fibers, Skeletal,
pubmed-meshheading:18804115-Muscle Proteins,
pubmed-meshheading:18804115-Peptide Elongation Factor 1,
pubmed-meshheading:18804115-Troponin T,
pubmed-meshheading:18804115-Tumor Necrosis Factor-alpha,
pubmed-meshheading:18804115-Ubiquitin,
pubmed-meshheading:18804115-Ubiquitin-Protein Ligases
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pubmed:year |
2008
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pubmed:articleTitle |
Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice.
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pubmed:affiliation |
Heart Center Leipzig, University Leipzig, Strümpellstrasse 39, D-04289 Leipzig, Germany. adav@medizin.uni-leipzig.de
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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