| pubmed-article:18798730 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C0348013 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C0006100 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C0018684 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C0264716 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C0242264 | lld:lifeskim |
| pubmed-article:18798730 | lifeskim:mentions | umls-concept:C1522326 | lld:lifeskim |
| pubmed-article:18798730 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18798730 | pubmed:dateCreated | 2009-1-29 | lld:pubmed |
| pubmed-article:18798730 | pubmed:abstractText | In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P<0.001 compared with baseline; ARB-treated CHF patients maximum 9.3+/-3.3%, P<0.05 compared with baseline; P=not significant for difference between groups), but the increase in unstressed volume in ACEI-treated CHF patients was higher (maximum 28.8+/-7.8%, P<0.001 compared with baseline; P<0.05 for the difference between groups). In contrast, while the increase in blood flow in healthy volunteers (maximum 362+/-9%, P<0.001) and in ACEI-treated CHF patients (maximum 376+/-12%, P<0.001) was similar (P=not significant for the difference between groups), the increase in ARB-treated CHF patients was less (maximum 335+/-7%, P<0.001; P<0.05 for the difference between groups). Infusion of each receptor antagonist alone similarly reduced basal unstressed volume and blood flow in ACEI-treated CHF patients, but not in healthy volunteers or ARB-treated CHF patients. In conclusion, bradykinin does not contribute to basal venous tone in health, but in ACEI-treated chronic heart failure it does. In ARB-treated heart failure, venous responses to bradykinin are preserved but arterial responses are reduced compared with healthy controls. Bradykinin-mediated vascular responses in both health and heart failure are mediated by the B2, rather than the B1, receptor. | lld:pubmed |
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| pubmed-article:18798730 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18798730 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18798730 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18798730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18798730 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18798730 | pubmed:issn | 1470-8736 | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:FrenneauxMich... | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:CampbellRossR | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:GunaruwanPras... | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:SchmittMatthi... | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:WilliamsLynne... | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:SharmanJamesJ | lld:pubmed |
| pubmed-article:18798730 | pubmed:author | pubmed-author:MaherAbdulA | lld:pubmed |
| pubmed-article:18798730 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18798730 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:18798730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18798730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18798730 | pubmed:pagination | 443-50 | lld:pubmed |
| pubmed-article:18798730 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18798730 | pubmed:meshHeading | pubmed-meshheading:18798730... | lld:pubmed |
| pubmed-article:18798730 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18798730 | pubmed:articleTitle | Effects of bradykinin on venous capacitance in health and treated chronic heart failure. | lld:pubmed |
| pubmed-article:18798730 | pubmed:affiliation | Department of Cardiovascular Medicine, Medical School, University of Birmingham, Edgbaston, UK. gunaruwan@doctors.org.uk | lld:pubmed |
| pubmed-article:18798730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18798730 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
