Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0000970,
umls-concept:C0030685,
umls-concept:C0331858,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0812409,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1521970,
umls-concept:C1533691,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1707455,
umls-concept:C1963578
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-9-30
|
| pubmed:abstractText |
An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled-release system, the Gradient Matrix System (GMS-1 and GMS-2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter-subject variability. GMS-1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time-scaling of the release data.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0142-2782
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
367-73
|
| pubmed:dateRevised |
2010-12-1
|
| pubmed:meshHeading | |
| pubmed:year |
1991
|
| pubmed:articleTitle |
Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems.
|
| pubmed:affiliation |
Pharmaceutical Development Department, Duphar BV, Weesp, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|