Pediatric bipolar disorder (PBD) presents with severe affect dysregulation characterized by elated mood, irritability and depressive symptoms, often in the form of a mixed episode. Early recognition of the external clinical features and the underlying emotional processing circuitry will help us understand the neurobiological underpinnings of this disorder and offer innovative ideas for early intervention.
Center for Cognitive Medicine & Institute for Juvenile Research, University of Illinois at Chicago, 912 South Wood Street (M/C 913), Chicago, IL 60612, USA. mpavuluri@psych.uic.edu
