|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2008-8-11
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|
pubmed:abstractText |
Rifampicin (rifampin) has been reported to have drug-drug interaction with several 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors due to its ability to influence the function of cytochrome P450 enzymes or transporters. Rosuvastatin is absorbed from the blood into the liver by organic anion transporting polypeptide 1B1 and is then metabolized by cytochrome P450 isozyme 2C9.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0149-2918
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1283-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:18691987-Adult,
pubmed-meshheading:18691987-Antibiotics, Antitubercular,
pubmed-meshheading:18691987-Cross-Over Studies,
pubmed-meshheading:18691987-Drug Interactions,
pubmed-meshheading:18691987-Fluorobenzenes,
pubmed-meshheading:18691987-Humans,
pubmed-meshheading:18691987-Hypolipidemic Agents,
pubmed-meshheading:18691987-Male,
pubmed-meshheading:18691987-Pyrimidines,
pubmed-meshheading:18691987-Rifampin,
pubmed-meshheading:18691987-Single-Blind Method,
pubmed-meshheading:18691987-Sulfonamides
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study.
|
|
pubmed:affiliation |
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China.
|
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
