|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0008328,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021853,
umls-concept:C0023764,
umls-concept:C0070358,
umls-concept:C0076275,
umls-concept:C0086045,
umls-concept:C0232461,
umls-concept:C0376674,
umls-concept:C0599946
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|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-10-9
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|
pubmed:abstractText |
Intestinal lipase inhibition using tetrahydrolipstatin (Orlistat) has been widely used in the pharmacotherapy of morbid obesity. However, the effects of Orlistat on the secretion of appetite regulating gastrointestinal hormones and appetite sensations are still debated. We addressed whether Orlistat alters the secretion of glucagon-like peptide-1-(7-36)-amide (GLP-1), cholecystokinin (CCK), peptide YY (PYY), and ghrelin as well as postprandial appetite sensations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
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pubmed:issn |
0021-972X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3995-8
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pubmed:meshHeading |
pubmed-meshheading:18647814-Administration, Oral,
pubmed-meshheading:18647814-Adult,
pubmed-meshheading:18647814-Animals,
pubmed-meshheading:18647814-Appetite,
pubmed-meshheading:18647814-Cholecystokinin,
pubmed-meshheading:18647814-Enzyme Inhibitors,
pubmed-meshheading:18647814-Gastric Emptying,
pubmed-meshheading:18647814-Glucagon-Like Peptide 1,
pubmed-meshheading:18647814-Humans,
pubmed-meshheading:18647814-Intestines,
pubmed-meshheading:18647814-Lactones,
pubmed-meshheading:18647814-Lipase,
pubmed-meshheading:18647814-Peptide Fragments,
pubmed-meshheading:18647814-Peptide YY,
pubmed-meshheading:18647814-Placebos,
pubmed-meshheading:18647814-Postprandial Period,
pubmed-meshheading:18647814-Rats,
pubmed-meshheading:18647814-Satiety Response,
pubmed-meshheading:18647814-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations.
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pubmed:affiliation |
Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany. mark.ellrichmann@rub.de
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial
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