Linked Life Data

18625768

Source:http://linkedlifedata.com/resource/pubmed/id/18625768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-9-25
pubmed:abstractText
Previous studies using in vivo candidiasis models have demonstrated that the concentration-associated pharmacodynamic indices, the maximum concentration of a drug in serum/MIC and 24-h area under the curve (AUC)/MIC, are associated with echinocandin treatment efficacy. The current investigations used a neutropenic murine model of disseminated Candida albicans and C. glabrata infection to identify the 24-h AUC/MIC index target associated with a stasis and killing endpoint for the echinocandin, micafungin. The kinetics after intraperitoneal micafungin dosing were determined in neutropenic infected mice. Peak levels and AUC values were linear over the 16-fold dose range studied. The serum drug elimination half-life ranged from 7.5 to 16 h. Treatment studies were conducted with 4 C. albicans and 10 C. glabrata isolates with micafungin MICs varying from 0.008 to 0.25 microg/ml to determine whether similar 24-h AUC/MIC ratios were associated with efficacy. The free drug AUC/MICs associated with stasis and killing (1-log) endpoints were near 10 and 20, respectively. The micafungin exposures associated with efficacy were similar for the two Candida species. Furthermore, the free drug micafungin exposures required to produce stasis and killing endpoints were similar to those recently reported for another echinocandin, anidulafungin, against the identical Candida isolates in this model.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-10091029, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-10471550, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-10722494, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-10722525, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-11181381, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-11751105, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12019101, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12461036, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12490683, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12654644, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12654645, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-12942393, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-14550704, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-15031728, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-15456349, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-15673762, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16172179, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16304173, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16464893, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16511756, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16575738, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16614256, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16716141, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16779750, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16801416, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16801435, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-16940061, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17021079, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17116670, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17143821, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17194830, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17223626, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17307976, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17307987, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17334728, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17420211, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17482982, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17568028, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17721682, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-17806055, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-18024052, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-18070979, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-1929288, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-9078447, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-9114154, http://linkedlifedata.com/resource/pubmed/commentcorrection/18625768-9455502
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1098-6596
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3497-503
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model.
pubmed:affiliation
Department of Medicine, University of Wisconsin, 600 Highland Ave., Madison, WI 53792, USA. dra@medicine.wisc.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't