| pubmed-article:18604872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C1522602 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C1538115 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18604872 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18604872 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18604872 | pubmed:dateCreated | 2008-8-11 | lld:pubmed |
| pubmed-article:18604872 | pubmed:abstractText | WWP1 is a ubiquitin ligase, associated with the post-translational regulation of several tumour-promoting and tumour suppressor proteins. Here we show that WWP1 expression is up-regulated in a subset of breast tumour cell lines and primary breast tumours. We overexpressed WWP1 in MCF10A breast epithelial cells and demonstrated increased cell growth and anchorage-independent colony formation. RNAi knockdown of WWP1 expression in T47D and MCF7 breast tumour cell lines reduced anchorage-independent colony formation. We used WWP1 protein expression levels, in combination with its sub-cellular localization, to classify breast tumours into four categories. Surprisingly, a category with low/absent WWP1 expression displayed a consistently worse prognosis compared with WWP1-expressing tumours. Importantly, the association with disease-free survival was independent of the status of other commonly used prognostic indicators. Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours. | lld:pubmed |
| pubmed-article:18604872 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18604872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18604872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18604872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18604872 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18604872 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:BaronMM | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:ChiuMM | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:PoulsomRR | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:HanbyA MAM | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:ClarkeR BRB | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:ZepsNN | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:FlaszaMM | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:RyderW D JWD | lld:pubmed |
| pubmed-article:18604872 | pubmed:author | pubmed-author:Nguyen HuuN... | lld:pubmed |
| pubmed-article:18604872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18604872 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:18604872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18604872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18604872 | pubmed:pagination | 93-102 | lld:pubmed |
| pubmed-article:18604872 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
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| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:meshHeading | pubmed-meshheading:18604872... | lld:pubmed |
| pubmed-article:18604872 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18604872 | pubmed:articleTitle | Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator. | lld:pubmed |
| pubmed-article:18604872 | pubmed:affiliation | University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. | lld:pubmed |
| pubmed-article:18604872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18604872 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18604872 | lld:pubmed |
