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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Signaling pathways usually activate transcriptional targets in a cell type-specific manner. Notable exceptions are pathway-specific feedback antagonists, which serve to restrict the range or duration of the signal. These factors are often activated by their respective pathways in a broad array of cell types. For example, the Wnt ligand Wingless (Wg) activates the naked cuticle (nkd) gene in all tissues examined throughout Drosophila development. How does the nkd gene respond in such an unrestricted manner to Wg signaling? Analysis in cell culture revealed regions of the nkd locus that contain Wg response elements (WREs) that are directly activated by the pathway via the transcription factor TCF. In flies, Wg signaling activates these WREs in multiple tissues, in distinct but overlapping patterns. These WREs are necessary and largely sufficient for nkd expression in late stage larval tissues, but only contribute to part of the embryonic expression pattern of nkd. These results demonstrate that nkd responsiveness to Wg signaling is achieved by several WREs which are broadly (but not universally) activated by the pathway. The existence of several WREs in the nkd locus may have been necessary to allow the Wg signaling-Nkd feedback circuit to remain intact as Wg expression diversified during animal evolution.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-10693810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11051548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11056799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11258709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11274052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11563973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11743020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-11783990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-12000788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-12015286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-12015973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-12482712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-12966081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-14981519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-15128670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-15330865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-16261625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-16710294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-16713950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-16849595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-17410209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-18160255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-18160704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-18174108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-2126897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-7813765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8262072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8330528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8424170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8565833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8769644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-8846894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9118221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9118222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9187151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9335506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9502727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9733572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18585374-9822716
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1095-564X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
446-54
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pubmed:dateRevised |
2011-5-27
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pubmed:meshHeading |
pubmed-meshheading:18585374-Animals,
pubmed-meshheading:18585374-Chromatin Immunoprecipitation,
pubmed-meshheading:18585374-Drosophila,
pubmed-meshheading:18585374-Drosophila Proteins,
pubmed-meshheading:18585374-Gene Expression Regulation, Developmental,
pubmed-meshheading:18585374-In Situ Hybridization,
pubmed-meshheading:18585374-RNA Interference,
pubmed-meshheading:18585374-Response Elements,
pubmed-meshheading:18585374-Signal Transduction,
pubmed-meshheading:18585374-T Cell Transcription Factor 1,
pubmed-meshheading:18585374-Wnt1 Protein
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pubmed:year |
2008
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pubmed:articleTitle |
Regulation of the feedback antagonist naked cuticle by Wingless signaling.
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pubmed:affiliation |
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Avenue, Ann Arbor, MI 48109-1048, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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