Linked Life Data

18570470

Source:http://linkedlifedata.com/resource/pubmed/id/18570470

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pubmed-article:18570470pubmed:abstractTextTwenty constituents were isolated from the n-hexane and chloroform extracts of Aristolochia constricta, a plant whose aerial parts have been used empirically in folk medicine for various purposes. The inhibitory effects of these constituents on smooth muscle contraction in isolated guinea-pig ileum were studied in order to observe their antispasmodic effects. 3,4-Dibenzyldihydrofuran-type lignans [(-)-cubebin, (-)-hinokinin, and (-)-pluviatolide] and a kaurene-type diterpene [(-)-kaur-16-en-19-oic acid] were isolated as active principals. They inhibited electrically induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. In addition, 9- O-[(-)-kaur-15-en-17-oxyl]cubebin was isolated as a new diterpeno-lignan hybrid, although this constituent did not exhibit antispasmodic activity.lld:pubmed
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pubmed-article:18570470pubmed:year2008lld:pubmed
pubmed-article:18570470pubmed:articleTitleChemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.lld:pubmed
pubmed-article:18570470pubmed:affiliationGraduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.lld:pubmed
pubmed-article:18570470pubmed:publicationTypeJournal Articlelld:pubmed
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